Comprehensive Leukemia Panel

 

A comprehensive leukemia panel, such as the one offered by Mapmygenome, is a genetic test designed to identify mutations and alterations associated with various types of leukemia. These panels typically include a range of tests to analyze genes commonly implicated in leukemia and other hematological malignancies. Here‘s an overview of what you might expect from such a panel:

1. Gene Panel Components

• Targeted Genes: The panel usually includes genes known to be associated with different types of leukemia, such as AML (Acute Myeloid Leukemia), ALL (Acute Lymphoblastic Leukemia), CLL (Chronic Lymphocytic Leukemia), and CML (Chronic Myeloid Leukemia). These genes might include, but are not limited to:
  • FLT3
  • NPM1
  • TP53
  • JAK2
  • BCR-ABL1
  • IDH1/2
  • KIT
  • RUNX1
  • ASXL1

2. Types of Tests Included

• DNA Sequencing: To identify point mutations and small indels in specific genes.
• Gene Fusion Analysis: To detect gene fusions such as BCR-ABL1 which is characteristic of CML.
• Copy Number Variation Analysis: To assess deletions, amplifications, and other large-scale genomic changes.
• Methylation Studies: In some cases, to explore epigenetic changes affecting gene expression.

3. Purpose and Benefits

• Diagnosis: Helps in confirming a diagnosis of leukemia and differentiating between subtypes.
• Prognosis: Provides information on likely disease progression and patient outcomes.
• Treatment Planning: Assists in tailoring treatment strategies based on specific genetic alterations.
• Monitoring: Helps in tracking minimal residual disease (MRD) and detecting relapses.

4. Process

• Sample Collection: Typically involves a blood sample or bone marrow biopsy.
• Analysis: The sample is analyzed in a laboratory to identify relevant genetic mutations and alterations.
• Results Interpretation: Results are reviewed by a geneticist or oncologist to provide insights specific to the patient‘s condition.

 

If you have specific questions about the Mapmygenome comprehensive leukemia panel, including how to interpret the results or its suitability for your situation, consulting with a healthcare provider or our genetic counselor would be beneficial.

 

Quick Product Overivew: 

https://open.spotify.com/episode/3l0VgkW1b3EAJjRIkQQl8J?si=kHCEFlTqQ82bQGHwi8d8yQ