FISH - Postnatal

FISH Postnatal Testing

Fluorescence In Situ Hybridization (FISH) is a crucial cytogenetic technique designed to detect specific chromosomal abnormalities. It has gained prominence as a postnatal diagnostic tool due to its targeted approach, enabling the identification of various genetic conditions in newborns and children. FISH testing plays an essential role in validating prenatal results, confirming suspicions of chromosomal abnormalities, and aiding in the diagnosis of conditions caused by microdeletions, trisomies, or other chromosomal disorders.

The ACMG (American College of Medical Genetics) and ASHG (American Society of Human Genetics) emphasize the importance of FISH in genetic testing, recommending that FISH results be combined with other diagnostic tests, such as chromosome analysis, to guide clinical decisions. In a postnatal context, FISH delivers rapid, reliable insights that can transform the course of medical care for children suspected of having genetic abnormalities.

FISH testing uses a specific fluorescent dye linked to a DNA probe, designed to bind to specific regions of chromosomes. By analyzing fluorescent signals under a microscope, clinicians can detect chromosomal abnormalities at a molecular level. These abnormalities may include extra copies (trisomies), missing sections (deletions), or rearrangements of chromosomes that can affect normal development and health.

Key conditions that FISH targets include:

FISH testing is different from broader genetic testing techniques, such as karyotyping or chromosomal microarray analysis (CMA), as it focuses on specific chromosomal regions rather than examining the entire genome. This targeted analysis is particularly useful when a specific genetic abnormality is suspected, and quick results are needed for medical intervention.

Clinical Utility of FISH Postnatal Testing

FISH postnatal testing offers several clinical benefits, especially in situations where precision and rapid results are crucial for medical decision-making. Some of its key applications include:

When to Consider FISH Postnatal Testing

FISH postnatal testing is recommended in various clinical scenarios, particularly when rapid or targeted genetic information is essential for decision-making. Key situations where FISH testing should be considered include:

MapmyGenome Offerings for FISH Postnatal Testing

At MapmyGenome, we offer advanced FISH testing services designed to provide rapid, reliable, and precise genetic insights. Our offerings include:

Test specification

Technique

Variant types

TAT

Sample Requirements

FISH

AS + SV

6 - 7 days

3- 4 ml Blood in EDTA

 

Learn more:

Read: FISH Postnatal Testing for Genetic Clarity

Listen: Decoding Chromosomes: The Power of FISH Postnatal Testing

Watch: Uncovering Genetic Secrets: FISH Postnatal Testing Explained

FAQs




What is a FISH test?

The FISH (Fluorescence In Situ Hybridization) test is a cytogenetic technique used to detect and localize specific DNA sequences on chromosomes. It allows for the identification of chromosomal abnormalities, such as deletions, duplications, or translocations, by using fluorescently labeled DNA probes.

How does the post-natal FISH test work?

Why might someone need a post-natal FISH test?

What conditions can the FISH test detect?

How is the sample for a FISH test collected?

What preparation is needed before undergoing a FISH test?

How long does it take to get results from a FISH test?

What should I do if the FISH test results are abnormal?

Are there any risks or limitations associated with the FISH test?

Is the FISH test covered by insurance?