Lymphoma Panel

The lymphoma panel from Mapmygenome is designed to analyze genetic variations associated with various types of lymphoma. This panel helps in the diagnosis, prognosis, and treatment planning for patients with lymphoma. Here‘s a comprehensive look at what such a panel typically involves:

1. Gene Panel Components

• Targeted Genes: The panel includes genes known to be involved in different types of lymphoma, such as Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). Common genes may include:
  • BCL2 (related to follicular lymphoma)
  • MYC (associated with Burkitt lymphoma)
  • TP53 (tumor suppressor gene)
  • CD79B (related to diffuse large B-cell lymphoma)
  • PRDM1 (associated with multiple myeloma and some lymphomas)
  • ALK (anaplastic large cell lymphoma)
  • IGH (immunoglobulin heavy chain gene rearrangements)
  • JAK3 (associated with certain types of lymphomas)

2. Types of Tests Included

• DNA Sequencing: To detect point mutations and small genetic alterations in relevant genes.
• Gene Fusion Analysis: To identify gene fusions, such as the BCL2/IGH fusion seen in follicular lymphoma.
• Copy Number Variation Analysis: To detect larger genomic changes like amplifications or deletions.
• Methylation Analysis: To examine epigenetic changes that may affect gene expression and contribute to lymphoma development.

3. Purpose and Benefits

• Diagnosis: Assists in confirming the presence of lymphoma and distinguishing between its subtypes.
• Prognosis: Provides information about the likely course of the disease and patient outcomes.
• Treatment Planning: Helps in personalizing treatment strategies based on specific genetic findings.
• Monitoring: Useful for tracking disease progression and response to treatment.

4. Process

• Sample Collection: Typically involves a blood sample or biopsy of affected lymph nodes or other tissues.
• Laboratory Analysis: Genetic testing is performed in a lab to identify mutations, fusions, and other genetic changes.
• Result Interpretation: Results are interpreted by healthcare professionals, including oncologists and genetic counselors, to provide actionable insights.

 

5. Additional Information

• Updates and Advances: Lymphoma genetics is a rapidly evolving field, so it‘s beneficial to stay informed about new discoveries and updates in the panel.